QTLs for fasting glucose in young Europeans replicate previous findings for type 2 diabetes in 2q23-24 and other locations
نویسندگان
چکیده
Long before reaching diagnostic cut off levels for type 2 diabetes (T2D), fasting glucose can be a powerful risk marker for this disease. We conducted a genome-wide search for fasting glucose as a quantitative trait in 412 young Europeans sib-pairs including obese children, with adjustment for sex, age and BMI. We identified more QTLs specific of fasting glucose and more significant than would be found by simple chance estimated by permutation tests. The strongest linkage was on chromosome 2q (LOD=3.00) in a region previously linked to T2D as a disease. We also found linkage signals of fasting glucose with 7q (LOD=2.03), 8q (LOD=1.28), 17p (LOD=2.12), 17q (LOD=1.4) et 11p (LOD=1.33). These findings suggest that the quantitative genetics of fasting glucose could contribute to the search for T2D genes.
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